| Wilson PF, Nagasawa H, Warner CL, Fitzek MM, Little JB, Bedford JS, Radiation Sensitivity of Primary Fibroblasts from Hereditary Retinoblastoma Family Members and Some Apparently Normal Controls: Colony Formation Ability during Continuous Low-Dose-Rate Gamma Irradiation Radiation research169:483-94 2008 |
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| Venkatachalam P, de Toledo SM, Pandey BN, Tephly LA, Carter AB, Little JB, Spitz DR, Azzam EI, Regulation of normal cell cycle progression by flavin-containing oxidases Oncogene27:20-31 2007 |
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| Pinto M, Howell RW, Concomitant quantification of targeted drug delivery and biological response in individual cells BioTechniques43:64, 66-71 2007 |
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| Campa A, Ballarini F, Belli M, Cherubini R, Dini V, Esposito G, Friedland W, Gerardi S, Molinelli S, Ottolenghi A, Paretzke H, Simone G, Tabocchini MA, DNA DSB induced in human cells by charged particles and gamma rays: experimental results and theoretical approaches International journal of radiation biology81:841-54 2006 |
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| Pinto M, Azzam EI, Howell RW, Bystander responses in three-dimensional cultures containing radiolabelled and unlabelled human cells Radiation protection dosimetry122:252-5 2006 |
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| Yang H, Asaad N, Held KD, Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts Oncogene24:2096-103 2005 |
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| Sarsour EH, Agarwal M, Pandita TK, Oberley LW, Goswami PC, Manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblasts. J Biol Chem280(18):18033-41 2005 |
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| Ben-Omran TI, Cerosaletti K, Concannon P, Weitzman S, Nezarati MM, A patient with mutations in DNA Ligase IV: Clinical features and overlap with Nijmegen breakage syndrome. Am J Med Genet A137(3):283-7 2005 |
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| Jensen R, Glazer PM, Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proc Natl Acad Sci U S A101(16):6134-9 2004 |
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| Shao C, Furusawa Y, Kobayashi Y, Funayama T, Wada S, Bystander effect induced by counted high-LET particles in confluent human fibroblasts: a mechanistic study. FASEB J17(11):1422-7 2003 |
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| Jakob B, Scholz M, Taucher-Scholz G, Characterization of CDKN1A (p21) binding to sites of heavy-ion-induced damage: colocalization with proteins involved in DNA repair International journal of radiation biology78:75-88 2002 |
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| Azzam EI, De Toledo SM, Spitz DR, Little JB, Oxidative metabolism modulates signal transduction and micronucleus formation in
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| Barton GM, Medzhitov R, Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci U S A99(23):14943-5 2002 |
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| Azzam EI, de Toledo SM, Little JB, Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells. Proc Natl Acad Sci U S A98(2):473-8 2001 |
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| Smilenov LB, Dhar S, Pandita TK, Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment. Mol Cell Biol19:6963-71 1999 |
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| Dahlberg, Response of dermal fibroblast cultures from patients eith unusually severe responses to radiotherapy and from ataxia telangiectasia heterozygotes to fractionated radiation. Clin Cancer Res1:785 (1995):6963-71 1995 |
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| Goodwin E, Meyne J, Strand-specific FISH reveals orientation of chromosome 18 alphoid DNA. Cytogenet Cell Genet63:126-7 1993 |
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| Nagasawa H, Little JB, Tsang NM, Saunders E, Tesmer J, Strniste GF, Effect of dose rate on the survival of irradiated human skin fibroblasts. Radiat Res132:375-9 1992 |
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| Kastan MB, Zhan Q, el-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ Jr, A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell71:587-97 1992 |
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| Taylor YC, Zhang XF, Parsian AJ, Duncan PG, Image analysis-based measurement of DNA supercoiling changes in transformed and nontransformed human cell lines. Exp Cell Res197:222-8 1991 |
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| Taylor YC, Duncan PG, Zhang X, Wright WD, Differences in the DNA supercoiling response of irradiated cell lines from ataxia-telangiectasia versus unaffected individuals. Int J Radiat Biol59:359-71 1991 |
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| Sherman ML, Datta R, Hallahan DE, Weichselbaum RR, Kufe DW, Ionizing radiation regulates expression of the c-jun protooncogene. Proc Natl Acad Sci U S A87:5663-6 1990 |
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| Fornace AJ Jr, Papathanasiou MA, Hollander MC, Yarosh DB, Expression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells. Cancer Res50:7908-11 1990 |
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| Fornace AJ Jr, Alamo I Jr, Hollander MC, Lamoreaux E, Ubiquitin mRNA is a major stress-induced transcript in mammalian cells. Nucleic Acids Res17:1215-30 1989 |
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| Little JB, Dahlberg WK, Sensitization of noncycling human diploid cells to X-irradiation by pretreatment with 9-beta-D-arabinofuranosyladenine. Cancer Res49:838-42 1989 |
| PubMed ID: 2912556 |
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| Little JB, Nichols WW, Troilo P, Nagasawa H, Strong LC, Radiation sensitivity of cell strains from families with genetic disorders predisposing to radiation-induced cancer. Cancer Res49:4705-14 1989 |
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| Konefal JB, Taylor YC, The effects of altered fractionation schedules on the survival of human cell lines differing in their proliferative activity and repair capacity. Int J Radiat Oncol Biol Phys17:1007-13 1989 |
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| Nagasawa H, Little JB, Radiosensitivities of ten apparently normal human diploid fibroblast strains to cell killing, G2-phase chromosomal aberrations, and cell cycle delay. Cancer Res48:4535-8 1988 |
| PubMed ID: 3396006 |
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| Nagasawa H, Burke MJ, Little FF, McCone EF, Chan GL, Little JB, Multiple abnormalities in the ultraviolet light response of cultured fibroblasts derived from patients with the basal cell nevus syndrome. Teratog Carcinog Mutagen8:25-33 1988 |
| PubMed ID: 2897722 |
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| Nagasawa H, Kraemer KH, Shiloh Y, Little JB, Detection of ataxia telangiectasia heterozygous cell lines by postirradiation cumulative labeling index: measurements with coded samples. Cancer Res47:398-402 1987 |
| PubMed ID: 3791230 |
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| Heartlein MW, Tsuji H, Latt SA, 5-Bromodeoxyuridine-dependent increase in sister chromatid exchange formation in Bloom's syndrome is associated with reduction in topoisomerase II activity. Exp Cell Res169:245-54 1987 |
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| Zamansky GB, Chou IN, Environmental wavelengths of ultraviolet light induce cytoskeletal damage. J Invest Dermatol89:603-6 1987 |
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| Nove J, Little JB, Mayer PJ, Troilo P, Nichols WW, Hypersensitivity of cells from a new chromosomal-breakage syndrome to DNA-damaging agents. Mutat Res163:255-62 1986 |
| PubMed ID: 3785261 |
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| Hards RG, Benkovic SJ, Van Keuren ML, Graw SL, Drabkin HA, Patterson D, Assignment of a third purine biosynthetic gene (glycinamide ribonucleotide transformylase) to human chromosome 21. Am J Hum Genet39:179-85 1986 |
| PubMed ID: 3529945 |
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| Hards RG, Patterson D, Variation of glycinamide ribonucleotide synthetase levels during in vitro aging of human fibroblasts: implications for gene dosage studies. Mech Ageing Dev36:65-70 1986 |
| PubMed ID: 3762234 |
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| Van Keuren ML, Watkins PC, Drabkin HA, Jabs EW, Gusella JF, Patterson D, Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids. Am J Hum Genet38:793-804 1986 |
| PubMed ID: 3014865 |
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| Geard CR, Georgsson MA, Glutathione levels and cytotoxicity of a thiol activated alkylating agent in human and mouse cells. Int J Radiat Oncol Biol Phys12:1179-82 1986 |
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| Zeman EM, Brown JM, Lemmon MJ, Hirst VK, Lee WW, SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int J Radiat Oncol Biol Phys12:1239-42 1986 |
| PubMed ID: 3744945 |
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| Kano Y, Little JB, Site-specific chromosomal rearrangements induced in human diploid cells by x-irradiation. Cytogenet Cell Genet41:22-9 1986 |
| PubMed ID: 3943368 |
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| Fornace AJ Jr, Kinsella TJ, Dobson PP, Mitchell JB, Repair of ionizing radiation DNA base damage in ataxia-telangiectasia cells. Cancer Res46:1703-6 1986 |
| PubMed ID: 3004702 |
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| Zamansky GB, Recovery from UV-induced potentially lethal damage in systemic lupus erythematosus skin fibroblasts. Int J Radiat Biol Relat Stud Phys Chem Med50:305-12 1986 |
| PubMed ID: 3488287 |
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| Zamansky GB, Varying sensitivity of human skin fibroblasts to polychromatic ultraviolet light. Mutat Res160:55-60 1986 |
| PubMed ID: 3951456 |
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| Sheela S, Kennedy AR, Radiation-induced anchorage-independent growth and collagenase production in diploid human fibroblasts. Carcinogenesis7:201-5 1986 |
| PubMed ID: 3004774 |
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| Schwenn MR, Weichselbaum RR, Little JB, Investigation of the cytotoxic effects of DNA damaging agents on neurofibromatosis cells. Mutat Res142:55-8 1985 |
| PubMed ID: 3919286 |
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| Little JB, Nagasawa H, Weichselbaum RR, Lovett DR, Schmit A, Kochenburger RJ, Blumberg PM, Differing patterns of cytotoxicity of the phorbol ester 12-O- tetradecanoylphorbol 13-acetate in various human cell strains. Carcinogenesis6:1703-8 1985 |
| PubMed ID: 3864565 |
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| Nagasawa H, Latt SA, Lalande ME, Little JB, Effects of X-irradiation on cell-cycle progression, induction of chromosomal aberrations and cell killing in ataxia telangiectasia (AT) fibroblasts. Mutat Res148:71-82 1985 |
| PubMed ID: 3969079 |
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| Kano Y, Little JB, Mechanisms of human cell neoplastic transformation: relationship of specific abnormal clone formation to prolonged lifespan in X-irradiated human diploid fibroblasts. Int J Cancer36:407-13 1985 |
| PubMed ID: 4030141 |
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| Weichselbaum RR, Tomkinson K, Little JB, Repair of potentially lethal X-ray damage in fibroblasts derived from patients with hereditary and D-deletion retinoblastoma. Int J Radiat Biol Relat Stud Phys Chem Med47:445-56 1985 |
| PubMed ID: 3872857 |
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| Kano Y, Little JB, Mechanisms of human cell neoplastic transformation: X-ray-induced abnormal clone formation in long-term cultures of human diploid fibroblasts. Cancer Res45:2550-5 1985 |
| PubMed ID: 3986793 |
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| Cheng YS, Becker-Manley MF, Chow TP, Horan DC, Affinity purification of an interferon-induced human guanylate-binding protein and its characterization. J Biol Chem260:15834-9 1985 |
| PubMed ID: 3934165 |
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| Zamansky GB, Minka DF, Deal CL, Hendricks K, The in vitro photosensitivity of systemic lupus erythematosus skin fibroblasts. J Immunol134:1571-6 1985 |
| PubMed ID: 3968426 |
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| Cornforth MN, Bedford JS, On the nature of a defect in cells from individuals with ataxia- telangiectasia. Science227:1589-91 1985 |
| PubMed ID: 3975628 |
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| Grafstrom RC, Fornace A Jr, Harris CC, Repair of DNA damage caused by formaldehyde in human cells. Cancer Res44:4323-7 1984 |
| PubMed ID: 6467194 |
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| Kano Y, Little JB, Persistence of X-ray-induced chromosomal rearrangements in long-term cultures of human diploid fibroblasts. Cancer Res44:3706-11 1984 |
| PubMed ID: 6744287 |
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| LeMotte PK, Little JB, DNA damage induced in human diploid cells by decay of incorporated radionuclides. Cancer Res44:1337-42 1984 |
| PubMed ID: 6704953 |
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| Kennedy AR, Radner BS, Nagasawa H, Protease inhibitors reduce the frequency of spontaneous chromosome abnormalities in cells from patients with Bloom syndrome. Proc Natl Acad Sci U S A81:1827-30 1984 |
| PubMed ID: 6584916 |
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| Kufe DW, Weichselbaum R, Egan EM, Dahlberg W, Fram RJ, Lethal effects of 1-beta-D-arabinofuranosylcytosine incorporation into deoxyribonucleic acid during ultraviolet repair. Mol Pharmacol25:322-6 1984 |
| PubMed ID: 6700578 |
| |
| Nagasawa H, Little JB, Suppression of cytotoxic effect of mitomycin-C by superoxide dismutase in Fanconi's anemia and dyskeratosis congenita fibroblasts. Carcinogenesis4:795-9 1983 |
| PubMed ID: 6409437 |
| |
| Nagasawa H, Little JB, Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts. Mutat Res109:297-308 1983 |
| PubMed ID: 6843573 |
| |
| Cornforth MN, Bedford JS, X-ray--induced breakage and rejoining of human interphase chromosomes. Science222:1141-3 1983 |
| PubMed ID: 6648528 |
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| Grosovsky AJ, Little JB, Mutagenesis and lethality following S phase irradiation of xeroderma pigmentosum and normal human diploid fibroblasts with ultraviolet light. Carcinogenesis4:1389-93 1983 |
| PubMed ID: 6640842 |
| |
| Li FP, Little JB, Bech-Hansen NT, Paterson MC, Arlett C, Garnick MB, Mayer RJ, Acute leukemia after radiotherapy in a patient with Turcot's syndrome. Impaired colony formation in skin fibroblast cultures after irradiation. Am J Med74:343-8 1983 |
| PubMed ID: 6572034 |
| |
| Chan GL, Little JB, Cultured diploid fibroblasts from patients with the nevoid basal cell carcinoma syndrome are hypersensitive to killing by ionizing radiation. Am J Pathol111:50-5 1983 |
| PubMed ID: 6837723 |
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| Grosovsky AJ, Little JB, Effect of growth rate on phenotypic expression of 6-thioguanine resistance in human diploid fibroblasts. Mutat Res110:163-70 1983 |
| PubMed ID: 6865995 |
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| Grosovsky AJ, Little JB, Influence of confluent holding time on UV light mutagenesis in human diploid fibroblasts. Mutat Res110:401-12 1983 |
| PubMed ID: 6877263 |
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| LeMotte PK, Little JB, A comparison of the lethal effects of intracellular radionuclides in human and rodent cells. Radiat Res95:359-69 1983 |
| PubMed ID: 6611854 |
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| Zamansky GB, Arundel C, Nagasawa H, Little JB, Adaptation of human diploid fibroblasts in vitro to serum from different sources. J Cell Sci61:289-97 1983 |
| PubMed ID: 6885940 |
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| Cornforth MN, Bedford JS, High-resolution measurement of breaks in prematurely condensed chromosomes by differential staining. Chromosoma88:315-8 1983 |
| PubMed ID: 6653204 |
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| Barfknecht TR, Little JB, Survival of hereditary retinoblastoma human skin fibroblasts after treatment with DNA-damaging chemicals. Mutat Res105:189-94 1982 |
| PubMed ID: 6815522 |
| |
| Barfknecht TR, Little JB, Abnormal sensitivity of skin fibroblasts from familial polyposis patients to DNA alkylating agents. Cancer Res42:1249-54 1982 |
| PubMed ID: 6800649 |
| |
| Kinsella TJ, Mitchell JB, McPherson S, Russo A, Tietze F, In vitro X-ray sensitivity in ataxia telangiectasis homozygote and heterozygote skin fibroblasts under oxic and hypoxic conditions. Cancer Res42:3950-6 1982 |
| PubMed ID: 7104995 |
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| Seres DS, Fornace AJ Jr, Normal response of fanconi's anemia cells to high concentrations of O2 as determined by alkaline elution. Biochim Biophys Acta698:237-42 1982 |
| PubMed ID: 7138867 |
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| LeMotte, The relative toxicity of intracellular radioisotopes in human and rodent cells. Radiat Res91:302 (1982):237-42 1982 |
| PubMed ID: 7138867 |
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| Fornace AJ Jr, Detection of DNA single-strand breaks produced during the repair of damage by DNA-protein cross-linking agents. Cancer Res42:145-9 1982 |
| PubMed ID: 7198506 |
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| Fornace AJ Jr, Seres DS, Repair of trans-Pt(II) diamminedichloride DNA-protein crosslinks in normal and excision-deficient human cells. Mutat Res94:277-84 1982 |
| PubMed ID: 7202118 |
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| Barfknecht TR, Little JB, Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA alkylating agents. Mutat Res94:369-82 1982 |
| PubMed ID: 6810166 |
| |
| Zamansky GB, Little JB, Survival of 60Co-irradiated herpes simplex virus in 15 human diploid fibroblast cell strains. Mutat Res94:245-55 1982 |
| PubMed ID: 6287252 |
| |
| Kinsella TJ, Little JB, Nove J, Weichselbaum RR, Li FP, Meyer RJ, Marchetto DJ, Patterson WB, Heterogeneous response to X-ray and ultraviolet light irradiations of cultured skin fibroblasts in two families with Gardner's Syndrome. J Natl Cancer Inst68:697-701 1982 |
| PubMed ID: 6951083 |
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| Fornace AJ Jr, Measurement of M. luteus endonuclease-sensitive lesions by alkaline elution. Mutat Res94:263-76 1982 |
| PubMed ID: 7110177 |
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| Nove J, Nichols WW, Weichselbaum RR, Little JB, Abnormalities of human chromosome 13 and in vitro radiosensitivity; a study of 19 fibroblast strains. Mutat Res84:157-67 1981 |
| PubMed ID: 7329430 |
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| Chan GL, Little JB, Cross-sensitivity of certain xeroderma pigmentosum and Cockayne syndrome fibroblast strains to both ionizing radiation and ultraviolet light. Mol Gen Genet181:562-3 1981 |
| PubMed ID: 6943407 |
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| Cox R, Masson WK, Weichselbaum RR, Nove J, Little JB, The repair of potentially lethal damage in x-irradiated cultures of normal and ataxia telangiectasia human fibroblasts. Int J Radiat Biol Relat Stud Phys Chem Med39:357-65 1981 |
| PubMed ID: 6971846 |
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| Weichselbaum RR, Nove J, Albert D, Little JB, An in vitro investigation of genetic susceptibility to cancer in diploid fibroblasts from retinoblastoma patients. Teratog Carcinog Mutagen1:171-9 1980 |
| PubMed ID: 6119809 |
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| Fornace AJ Jr, Little JB, Normal repair of DNA single-strand breaks in patients with ataxia telangiectasia. Biochim Biophys Acta607:432-7 1980 |
| PubMed ID: 6156701 |
| |
| Weichselbaum RR, Nove J, Little JB, X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders. Cancer Res40:920-5 1980 |
| PubMed ID: 7471105 |
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| Little JB, Nove J, Weichselbaum RR, Abnormal sensitivity of diploid skin fibroblasts from a family with gardner's syndrome to the lethal effects of X-irradiation, ultraviolet light and mitomycin-C. Mutat Res70:241-50 1980 |
| PubMed ID: 7374661 |