Overview

Collection	NINDS Repository
Subcollection	Parkinsonism
Sample Description	PARKINSON'S DISEASE LATE ONSET PARKINSON'S DNA PANEL, AFFECTED INDIVIDUALS PD PARKINSON'S PANEL: CAUCASIAN FROM THE UNITED STATES
This Sample Is Also in Other Products	NDPT089 [PARKINSON'S PANEL: CAUCASIAN FROM THE UNITED STATES ]
Biopsy Source	Peripheral vein
Cell Type	B-Lymphocyte
Tissue Type	Blood
Transformant	Epstein-Barr Virus
Species	Homo sapiens
Common Name	Human
Age At Sampling	70 YR
Sex	Female
Race	Caucasian
Hispanic Ethnicity	Not Hispanic/Latino
Country of Origin	USA
Family History	N
Clinically Affected	Yes
Catalog ID	ND00018
Product	Cell Culture
Pricing	Commercial Pricing: $500.00 Academic and not-for-profit pricing: $250.00
Catalog ID	ND00018
Product	DNA
Quantity	50 µg
Source	cell culture
Pricing	Commercial Pricing: $200.00 Academic and not-for-profit pricing: $100.00
How to Order	Online Ordering Assurance Form (Must have current form on file) Statement of Research Intent Form (Information will be entered electronically when order is placed. DO NOT fax form to Coriell Customer Service)

Characterizations

Sample Description	PARKINSON'S DISEASE LATE ONSET PARKINSON'S DNA PANEL, AFFECTED INDIVIDUALS PD PARKINSON'S PANEL: CAUCASIAN FROM THE UNITED STATES
DNA Profile
D10S526	190, 250
D22S417	177, 185
D5S592	178, 190
FES/FPS	220, 228
THO-1	159, 175
VWA31	149, 153

Phenotypic Data

Demographic Data
Relation to Proband	No Data
Subject Currect Age	70 YR
Gender	Female
Age of Onset(If not a control)	63 YR
Age at Diagnosis(If not a control)	63
Hispanic or Latino/Not Hispanic or Latino	Not Hispanic/Latino
Racial Category	Caucasian
Country	USA
Diagnosed By	No Data
Data Elements
Clinical Element Type: Parkinsonism
(Baseline)
Longitudinal Data
Is this data Longitudinal (Follow-Up) Data?	yes  no
Family History
Family history of parkinsonism	present  absent   unknown (subject adopted)
Specific diagnosis
Parkinsonism clinical diagnosis	Parkinson's disease Progressive Supranuclear Palsy Diffuse Lewy Body Disease Multiple System Atrophy Others Unaffected primary blood relative of proband
Mutation/s in subject's DNA (if present, describe)	present  absent  unknown
Signs suggestive of PD diagnosis
Asymmetric onset	No Data
Bradykinesis	present   absent
Activation tremor	No Data
Resting Tremor	present   absent
Postural Instability	No Data
Rigidity	present   absent
Gait difficulties	present   absent
Response to Anti-Parkinsonism Therapy	No Data
Signs suggestive of another diagnosis
history of strokes or stepwise deterioration	No Data
history of head injury with loss of consciousness	No Data
history of encephalitis	No Data
Oculogyric crisis	No Data
neuroleptic treatment at time of symptom onset	No Data
sustained remission	No Data
gaze palsy	No Data
cerebellar signs (other than activation tremor)	No Data
fluctuations	No Data
hallucinations	No Data
dysautonomia	No Data
memory loss	No Data
axial rigidity	No Data
Other	present  absent
Smoking History
smoking history	never   former smoker  current smoker
years smoking	No Data
Optional data
Mini-mental status score	No Data
Hoehn and Yahr	No Data
UPDRS total motor score	No Data
Handedness	No Data

Publications

Li Y, Rowland C, Schrodi S, Laird W, Tacey K, Ross D, Leong D, Catanese J, Sninsky J, Grupe A, A case-control association study of the 12 single-nucleotide polymorphisms implicated in Parkinson disease by a recent genome scan American journal of human genetics78:1090-2; author reply 1092-4 2006

PubMed ID: 16685663

External Links

dbSNP	dbSNP ID: 15825
OMIM	168600 PARKINSON DISEASE 1
Omim Description	PARKINSON DISEASE 1
	PARKINSON DISEASE; PD
	PARKINSONISM
dbGaP Link	phs000003.v1.p1

Images

Data are not available

Culture Protocols

Split Ratio	1:2
Temperature	37 C
Percent CO2	5%
Percent O2	AMBIENT
Medium	Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine
Serum	15% fetal bovine serum Not Inactivated
Substrate	None specified
Subcultivation Method	dilution - add fresh medium